1 in 6 People Who Stop Antidepressants Have Withdrawal Symptoms

The reality of antidepressant withdrawal—a term that covers a range of physical and mental symptoms—affects around 1 in 6 individuals who discontinue these medications. Although many can expect mild symptoms, a small subset of people may experience them more intensely, with symptoms extending well beyond the point of stopping. This new study suggests a careful perspective: it estimates that around 15 percent of people stopping antidepressants experience symptoms like dizziness, nausea, insomnia, and even “brain zaps”—sharp, electric-like jolts in the head that can be deeply unsettling. Published in The Lancet Psychiatry, the study points to severe withdrawal effects for roughly 1 in 35 individuals coming off antidepressants.


"Like all medications, antidepressants offer benefits but also present risks,” says Dr. Christopher Baethge, a study author and researcher at University Hospital Cologne’s psychiatry department. He emphasizes that many medications—not just antidepressants—can lead to withdrawal symptoms, underscoring the need for balanced, informed guidance for those considering a change.

Certain Antidepressants Bring Greater Withdrawal Challenges

The type of antidepressant significantly influences withdrawal experiences. According to the study, some medications like imipramine (Tofranil), paroxetine (Paxil), and venlafaxine (Effexor) are more likely to lead to intense withdrawal symptoms. In contrast, antidepressants such as fluoxetine (Prozac) and sertraline (Zoloft) show lower rates of withdrawal effects, possibly due to their slower release from the body. Dr. Lisa Fortuna, chair of psychiatry at the University of California, Riverside, notes that drugs leaving the system faster generally provoke stronger withdrawal symptoms. “Your body’s metabolism plays a large role in this,” she explains.

Most symptoms appear within days after stopping, and while many are temporary, some linger for weeks—or in rare cases, months. This variability underscores the importance of understanding how different drugs and individual metabolisms interact in these experiences.

Fewer People Affected Than Previously Thought?

While this study reaffirms that a notable number of people experience withdrawal symptoms, it also hints at a lower rate than previously estimated. Prior research suggested over half of those stopping antidepressants encountered withdrawal symptoms, with severe cases making up a large portion of that group. However, earlier studies, often observational, could not definitively pinpoint the exact cause of these symptoms. Dr. Baethge and his team sought clarity by analyzing randomized controlled trials, which offer a more precise gauge of drug-specific symptoms versus general side effects.

In analyzing 79 trials involving over 21,000 participants, they observed that a significant number—17 percent—of those taking placebos also reported symptoms, suggesting that many of the withdrawal symptoms might stem from factors unrelated to the medications themselves.

A Personalized Plan Is a Key for Tapering Off Antidepressants

Dr. Beth Salcedo, medical director of The Ross Center for Mental Health, notes that these findings validate what many psychiatrists have long advised: gradual tapering of doses and close contact with medical providers can make a significant difference. “Abrupt discontinuation, especially without clear expectations, can be frightening,” Salcedo points out. “Brain zaps, though harmless, are commonly reported and can be alarming.” She highlights the importance of discussing a tapering plan early in treatment, as this knowledge can be essential for those struggling with medication adherence.

Fortuna adds that discussing potential withdrawal symptoms can also empower patients to stay consistent with their medications. “Lack of knowledge on what to expect can turn this experience into a very frightening one,” she warns, stressing the value of good communication with healthcare providers.

For those considering discontinuing their antidepressant regimen, this research affirms the need for a well-planned approach, realistic expectations, and regular support from healthcare professionals to ease the journey.
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